TECHNOLOGY
The science behind the product at Icell Kealex
We have successfully engineered the NEVs of VV with the ability of escaping anti-VV Nabs effectively.
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We have armed the VV with T-cell engager as a potential means of engaging T-cells for tumor destruction.
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Targeting FAP+ cancer associated fibroblast promotes virus infiltration into and spread within the tumors.
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What is BiTE?BiTE stands for bispecific T-cell engager, a class of artifical bispecific monoclonal antibodies.A BiTE antibody is
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composed of two single chain variable fragments (scFv). A tumor-targeting scFv is combined with a T-cell activating ligand scFv. The opposing ends of the antibody bind tumor epitopes and T-cell receptors respectively. The resulting crosslinking causes T-cells to activate and release proteases and cytokines that destroy the tumor cell.
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